2-(Chloromethyl)-1,3-thiazole → 1-Nitro-2-(propynylamino)-2-{2-[(thiazol-2-yl)methylthio]ethylamino}ethylene

반응식

[N+:1]([CH:4]=[C:5]([NH:9][CH2:10][C:11]#[CH:12])CCS)([O-:3])=[O:2].Cl[CH2:14][C:15]1[S:16][CH:17]=[CH:18][N:19]=1>>[N+:1]([CH:4]=[C:5]([NH:9][C:10]#[C:11][CH3:12])[NH:19][CH2:18][CH2:17][S:16][CH2:14][C:15]1[S:16][CH:17]=[CH:18][N:19]=1)([O-:3])=[O:2]

참가 물질

반응물 2

HCID 140908642-(Chloromethyl)-1,3-thiazole

HCID 736839981-Nitro-2-(2-propynylamino)-2-(2-mercaptoethyl)ethylene

생성물 1

HCID 705971581-Nitro-2-(propynylamino)-2-{2-[(thiazol-2-yl)methylthio]ethylamino}ethylene

실험 절차

The product of Step A is reacted in a non-reactive solvent with about an equimolar amount of 2-chloromethylthiazole and about one equivalent of base, and the title product is thereby produced.

출처 및 근거

ORD 기록: ord-fd423d1c94a945868f2609729b2912de
출처 데이터셋: uspto-grants-1980_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04200578

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