Dicyclohexylcarbodiimide → 2-Propanone, O-(1-oxo-2-(4-(4-(trifluoromethyl)phenoxy)pheoxy)propyl)oxime

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After 15 g of 2-[p-(p-trifluoromethylphenoxy)phenoxy]-propionic acid are suspended in 20 ml of methylene chloride, 3.5 g of acetone oxime are added at room temperature. 9.8 g of dicyclohexylcarbodiimide, in 10 ml of methylene chloride, are then added dropwise over a period of 10 minutes as the temperature increases to about 40° C. The reaction mixture is then stirred at room temperature for 2 hours and filtered. The filtrate is evaporated to dryness on a rotary evaporator to yield acetone O-[2-[p-(p-trifluoromethylphenoxy)phenoxy]propionyl]-oxime, nD20 : 1.5212.

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