Potassium Cyanide → HCID 20342246, 화합물

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[C:1]1([CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:8]2[CH2:11][CH:10]([CH:12]=[O:13])[CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C-:20]#[N:21].[K+]>O.O1CCCC1>[OH:13][CH:12]([CH:10]1[CH2:11][N:8]([CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:9]1)[C:20]#[N:21]

참가 물질

실험 절차

To a solution of 1.13 g (4.49 mmoles) of crude 1-diphenylmethyl-3-formylazetidine in a mixture of 2 ml of water and 2 ml of tetrahydrofuran is added 878 mg (3 equivalents) of potassium cyanide, and the mixture is stirred at room temperature for 2 hours, mixed with water and extracted with methylene chloride. The extract is washed with water, dried, and evaporated to yield 1.046 g of crude 2-hydroxy-2-(1-diphenylmethylazetidin-3-yl)acetonitrile as hemi-solid product in 83% yield.