Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-Hydroxy-2-(1-benzylpyrrolidin-3-yl)acetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Cyanide | HCID 9032 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 1-Benzylpyrrolidine-3-carbaldehyde | HCID 4589478 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Hydroxy-2-(1-benzylpyrrolidin-3-yl)acetonitrile | HCID 20342257 | 84.7% |
반응 단계
To a solution of 12.45 g of crude 1-benzyl-3-formylpyrrolidine in a mixture of 23 ml of tetrahydrofuran and 23 ml of water is added 11.4 ml (2 equivalents) of concentrated hydrochloric acid and then 8.39 g (2 equivalents) of potassium cyanide powder in a period of 15 minutes under ice-cooling. The mixture is stirred at the same temperature for 2 hours, adjusted to pH 10 with 10% aqueous sodium carbonate solution, and extracted thrice with methylene chloride. The extract is washed with water, dried over sodium sulfate and evaporated under reduced pressure to yield 12.05 g of 2-hydroxy-2-(1-benzylpyrrolidin-3-yl) acetonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04200628 |
| 출처 데이터셋 | uspto-grants-1980_04 |
| ORD ID | ord-5299a62f2b5842b290a5b4acde50e4c2 |
| 출처 메모 | uspto-grants-1980_04 |