Propargylamine → HCID 178457409, 화합물

HRID 2050353

반응식

HRID 2050353 반응식
[N+:1]([CH:4]=[C:5](SC)[NH:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16])([O-:3])=[O:2].[CH2:19]([NH2:22])[C:20]#[CH:21]>C(#N)C>[N+:1]([CH:4]=[C:5]([NH:22][CH2:19][C:20]#[CH:21])[NH:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16])([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 239041PropargylamineHCID 178503826HCID 178503826, 화합물

생성물 1

HCID 178457409HCID 178457409, 화합물수율 87%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 1-nitro-2-methylthio-2-{2-[(4-methyl-1H-imidazol-5-yl)methylthio]ethylamino}ethylene prepared according to Belgian Pat. No. 814,941 (4.0 g, 0.014 mole) and distilled propargylamine (7.74 g, 0.14 mole) in acetonitrile (60 ml) was stirred at reflux temperature under a positive pressure of nitrogen for 18 hours. The reaction mixture was cooled, evaporated to dryness and then triturated under 20 ml of isopropyl alcohol to give the title compound (3.58 g, 87%). Column chromatography on silica gel by gradient elution using methylene chloride-methanol gave a pure sample; mp 159°-160° dec.

후처리

  1. customprepared
  2. temperatureat reflux temperature under a positive pressure of nitrogen for 18 hours
  3. temperatureThe reaction mixture was cooled
  4. customevaporated to dryness
  5. customtriturated under 20 ml of isopropyl alcohol

출처 및 근거

ORD 기록
ord-4658416d6d5c48be8cd2788594c4fcd1
출처 데이터셋
uspto-grants-1980_04
특허 번호
US04200760

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