HCID 86734330, 화합물 → cis-2-Aminomethyl-4-oxo-3-phenoxyacetylaminoazetidine

HRID 2050392노트

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HRID 2050392 반응식
[N:1]([CH2:4][C@H:5]1[C@@H:8]([NH:9][C:10](=[O:19])[CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:7](=[O:20])[NH:6]1)=[N+]=[N-]>[Pd].C(O)C>[NH2:1][CH2:4][C@H:5]1[C@@H:8]([NH:9][C:10](=[O:19])[CH2:11][O:12][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:7](=[O:20])[NH:6]1

참가 물질

4

반응물 1

HCID 86734330HCID 86734330, 화합물

생성물 1

HCID 70593118cis-2-Aminomethyl-4-oxo-3-phenoxyacetylaminoazetidine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A suspension of 0.499 g (1.81 mmole) of cis-2-azidomethyl-4-oxo-3-phenoxyacetylaminoazetidine and 0.189 g of 10% palladium on carbon in 25 ml of absolute ethanol was hydrogenated at atmospheric pressure and at 40° for 1 hour. The solution was filtered through celite and the solvent was removed in vacuo to afford the title compound as a colorless gum.

후처리

  1. filtrationThe solution was filtered through celite
  2. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-86f832a4941d43b1a9d4d2c1e18e7a04
출처 데이터셋
uspto-grants-1980_04
특허 번호
US04200572

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