1,1'-Carbonyldiimidazole → 7,8-Dihydro-8-(3-(trifluoromethyl)phenyl)-3H,6H-1,4,5a,8a-tetraazaacenaphthylene-3,5(4H)-dione
반응식
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:4]=[C:5]([CH:9]2[N:14]3[N:15]=[CH:16][C:17]([C:18]([NH2:20])=[O:19])=[C:13]3[NH:12][CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[C:23](N1C=CN=C1)(N1C=CN=C1)=[O:24]>O1CCCC1>[F:22][C:2]([F:21])([F:1])[C:3]1[CH:4]=[C:5]([CH:9]2[N:14]3[C:13]4[N:12]([C:23](=[O:24])[NH:20][C:18](=[O:19])[C:17]=4[CH:16]=[N:15]3)[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1참가 물질
4
실험 절차
To a 3.0 g portion of 4,5,6,7-tetrahydro-7-(3-(trifluoromethyl)phenyl)pyrazolo(1,5-a)pyrimidine-3-carboxamide (Example 13) suspended in 40 ml of dry tetrahydrofuran is added portionwise under nitrogen 8.0 g of 1,1'-carbonyldiimidazole and 60 ml of dry tetrahydrofuran. The reaction mixture is heated at reflux for 96 hours, and then is cooled to give a white precipitate which is collected by filtration. The precipitate is treated with 10 ml of water, filtered and dried to give 1.05 g of the desired product as a white solid, mp 297-300° C.