Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl propiolate → methyl (E)-3-[4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-yl]-2-propenoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl propiolate | HCID 13536 | — |
| 반응물 | 4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazole | HCID 14849776 | — |
| 생성물 | methyl (E)-3-[4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-yl]-2-propenoate | HCID 14849778 | 46.6% |
반응 단계
From 4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazole (2.00 g) and methyl propiolate (2.55 g) by the process as described for the preparation of Intermediate (7 a) to afford an orange solid which was purified by FCC eluting with System A (3:17) to afford the title compound (1.194 g) as a white solid. λmax (MeOH) 248.4 (22,180) and 300 (inf) nm (ε9410).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05013749 |
| 출처 데이터셋 | uspto-grants-1991_05 |
| ORD ID | ord-55f9218a62e54a6ab4ee821c4adb871a |
| 출처 메모 | uspto-grants-1991_05 |