참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Benzaldehyde | HCID 240 | — |
| 반응물 | Ammonium Acetate | HCID 517165 | — |
| 반응물 | ethyl-2-(N-tert-butylsulfamoyl)acetate | HCID 19833529 | — |
| 생성물 | Ethyl 3-phenyl-2-(tert.butylaminosulfonyl)prop-2-enoate | HCID 57037021 | 72% |
반응 단계
11.2 g (0.05 mol) of ethyl 2-(tert.butylaminosulfonyl)acetate (see J. Org. Chem. 43, p. 4535 (1978)) are dissolved in 50 ml of benzaldehyde, 2 g of ammonium acetate and 2 ml of glacial acetic acid are added, and the mixture is stirred for 2 hours at 60° C. under a water pump vacuum (20 mm). The excess aldehyde is subsequently distilled off, and the residue is digested using n-hexane and recrystallized from isopropanol. 11.2 g (72% of theory) of ethyl 3-phenyl-2-(tert.butylaminosulfonyl)prop-2-enoate of melting point 111°-113° C. are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05015284 |
|---|
| 출처 데이터셋 | uspto-grants-1991_05 |
|---|
| ORD ID | ord-50e92ea2e822489f80998c8691832cdf |
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| 출처 메모 | uspto-grants-1991_05 |
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