Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formaldehyde → 1-Benzyl-5-(hydroxymethyl)pyrrolidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | alpha-Methoxy-alpha-trifluoromethylphenylacetic acid, (-)- | HCID 6992788 | — |
| 반응물 | (S)-1-Benzyl-5-hydroxymethyl-2-pyrrolidinone | HCID 10442943 | — |
| 생성물 | 1-Benzyl-5-(hydroxymethyl)pyrrolidin-2-one | HCID 563061 | — |
반응 단계
The optical purity of the (S)-5-(hydroxymethyl)-1-(phenylmethyl)-2-pyrrolidinone was established by formation of the ester derived from (S)-(-)-α-methoxy-α-(trifluoromethyl)phenylacetic acid ((-)-MTPA) following the procedure of Mosher, et al. (J. Org. Chem. 1969, 34, 2543). A single diastereomeric ester, as judged by 1H NMR and TLC, was obtained, and could readily be differentiated from the diastereomeric mixture (by the doubling of the CH2N and CH2O signals in the 1H NMR) produced when racemic 5-(hydroxymethyl)-1-(phenylmethyl)-2-pyrrolidinone was used to form the (-)-MTPA ester.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05015653 |
| 출처 데이터셋 | uspto-grants-1991_05 |
| ORD ID | ord-f1ba3e151907454596a89e401942ec93 |
| 출처 메모 | uspto-grants-1991_05 |