Acetophenone → 1-(4-Methylphenyl)-3-phenylpropane-1,3-dione

HRID 2051052

반응식

HRID 2051052 반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].C[C:11]1[CH:12]=[C:13]([C:18]([O:20]C)=O)[C:14](C)=[CH:15][CH:16]=1.[CH3:22][O-].[Na+]>C1(C)C(C)=CC=CC=1>[C:1]([CH2:2][C:18](=[O:20])[C:13]1[CH:12]=[CH:11][C:16]([CH3:22])=[CH:15][CH:14]=1)(=[O:3])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 7410AcetophenoneHCID 273300Methyl 2,5-dimethylbenzoateHCID 10942334Sodium Methoxide

생성물 1

HCID 7811081-(4-Methylphenyl)-3-phenylpropane-1,3-dione

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

Acetophenone (30 grams; 0,25 mol), methyl p-methyltoluate (136 grams; 1.0 mol), xylene (300 ml) and sodium methoxide (17.3 grams; 0.3 mol) were placed into a four-necked round bottom one liter flask equipped as in Example 1. The mixture was heated with stirring to 135°-140° C. and maintained there for 6 hours under a blanket of nitrogen. The procedure set forth in Example 1 was used to recover the desired product, benzoyl p-methylbenzoylmethane (40 grams; 67 weight percent yield) having a purity of 66%.

후처리

  1. customequipped as in Example 1
  2. temperatureThe mixture was heated
  3. temperaturemaintained there for 6 hours under a blanket of nitrogen
  4. customto recover the desired product, benzoyl p-methylbenzoylmethane (40 grams; 67 weight percent yield)

출처 및 근거

ORD 기록
ord-7643653de6e9428088e520bee637b9e5
출처 데이터셋
uspto-grants-1991_05
특허 번호
US05015777

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