(3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate → Tert-butyl 4-{4-[3-(2,3-difluorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate

반응식

[Br:22][CH2:23][CH2:24][CH2:25][O:26][c:27]1[c:28]([F:34])[c:29]([F:33])[cH:30][cH:31][cH:32]1.[OH:1][CH:2]1[CH2:3][N:4]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][c:11]([OH:14])[cH:12][cH:13]1>>[OH:1][CH:2]1[CH2:3][N:4]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][c:11]([O:14][CH2:23][CH2:24][CH2:25][O:26][c:27]2[c:28]([F:34])[c:29]([F:33])[cH:30][cH:31][cH:32]2)[cH:12][cH:13]1

참가 물질

반응물 2

HCID 21713087(3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate

HCID 630386791-(3-Bromopropoxy)-2,3-difluorobenzene

생성물 1

HCID 68503837Tert-butyl 4-{4-[3-(2,3-difluorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate

출처 및 근거

ORD 기록: ord-2a7b81c0cd9d44c185bf4deb415317ab
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

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