HCID 136109365, 화합물 → HCID 135578121, 화합물

HRID 2051555노트

반응식

HRID 2051555 반응식
C([O:3][CH:4](OCC)[CH2:5][CH2:6][C:7]1[C:12](=[O:13])[NH:11][C:10]([NH:14][C:15](=[O:17])[CH3:16])=[N:9][C:8]=1[N:18]([C:22](=[O:24])[CH3:23])[C:19](=[O:21])[CH3:20])C>O>[C:15]([NH:14][C:10]1[NH:11][C:12](=[O:13])[C:7]([CH2:6][CH2:5][CH:4]=[O:3])=[C:8]([N:18]([C:22](=[O:24])[CH3:23])[C:19](=[O:21])[CH3:20])[N:9]=1)(=[O:17])[CH3:16]

참가 물질

3

반응물 1

HCID 136109365HCID 136109365, 화합물

생성물 1

HCID 135578121HCID 135578121, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 3-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propionaldehyde diethyl acetal (1.00 g, 2.6 mmol) in distilled water (30 ml) was stirred at room temperature for 18 hours. This solution was extracted with ethyl ether (3×50 ml), and chloroform (5×50 ml). The chloroform extracts were combined, washed with water (25 ml), brine (25 ml), dried (MgSO4) and spin evaporated in vacuo. The residue was recrystallized from chloroform/cyclohexane to yield 0.200 g (25% of theory) of analytically pure 3-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propionaldehyde quarter hydrate, mp 164°-168° C.

후처리

  1. extractionThis solution was extracted with ethyl ether (3×50 ml), and chloroform (5×50 ml)
  2. washwashed with water (25 ml), brine (25 ml)
  3. dry with materialdried (MgSO4)
  4. customspin evaporated in vacuo
  5. customThe residue was recrystallized from chloroform/cyclohexane

출처 및 근거

ORD 기록
ord-c0f8b2d64f214325b592149210859af2
출처 데이터셋
uspto-grants-1991_05
특허 번호
US05019577

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