Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → cis-Octahydroisoindole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | cis-Hexahydrophthalimide | HCID 6992236 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | cis-Octahydroisoindole | HCID 10964494 | — |
반응 단계
To a slurry of lithium aluminium hydride (17.1 g) in dry diethyl ether (375 ml) under a nitrogen atmosphere, cis-hexahydrophthalimide (23.0 g) in dry tetrahydrofuran (300 ml) was added over a two-hour period. The mixture was refluxed for 2.5 hours, cooled and treated very slowly with excess of water. The precipitate was filtered off and the filtrate was evaporated to yield the title compound as a viscous oil, which was used in the next step without purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04181659 |
| 출처 데이터셋 | uspto-grants-1980_01 |
| ORD ID | ord-d5fdc02a68d7413188ac41fca4b5cb6f |
| 출처 메모 | uspto-grants-1980_01 |