Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → (17beta)-17-(3-(4-(Hexyloxy)phenyl)-1-oxopropoxy)estr-4-en-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Nandrolone | HCID 9904 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | 3-[p-(Hexyloxy)phenyl]propionic acid | HCID 91287 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | (17beta)-17-(3-(4-(Hexyloxy)phenyl)-1-oxopropoxy)estr-4-en-3-one | HCID 92341 | 87% |
반응 단계
To a solution of 17β-hydroxyestr-4-en-3-one (5.48 g) and 3-(4-hexyloxyphenyl)propionic acid (5.75 g) in dry pyridine (60 ml) pTSA (0.200 g) and DCC (5.77 g) are added. After 72 h stirring at room temperature acetic acid (2 ml) is added, and the reaction mixture is kept overnight at +4° C. The same work-up procedure as in Example 1 gives 17β-[3-(4-hexyloxyphenyl)-propanoyloxy]estr-4-en-3-one (m. p. 52°-53° C.) in a 87% yield after recrystallization from methanol/water.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04181669 |
| 출처 데이터셋 | uspto-grants-1980_01 |
| ORD ID | ord-f3b0fc093dc74a3092f938dc6690a6f0 |
| 출처 메모 | uspto-grants-1980_01 |