5-Bromofuran-2-carbaldehyde → 1-(5-Bromofurfurylideneamino)-2,3-dioxo-piperazine

HRID 2051765

반응식

HRID 2051765 반응식
[Br:1][C:2]1[O:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[NH2:9][N:10]1[CH2:15][CH2:14][NH:13][C:12](=[O:16])[C:11]1=[O:17]>C(O)(=O)C>[Br:1][C:2]1[O:8][C:5]([CH:6]=[N:9][N:10]2[CH2:15][CH2:14][NH:13][C:12](=[O:16])[C:11]2=[O:17])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 6003285-Bromofuran-2-carbaldehydeHCID 221847681-Aminopiperazine-2,3-dione

생성물 1

HCID 538214971-(5-Bromofurfurylideneamino)-2,3-dioxo-piperazine수율 38.5%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

1.9 pts. by wt. of 5-bromofurfural, 1.3 pts. by wt. of 1-amino-2,3-dioxo-piperazine and 7 pts. by vol. of glacial acetic acid were warmed to 90° for 10 minutes and then left for 30 minutes at RT. The precipitate is filtered off, washed with 3 pts. by vol. of glacial acetic acid and recrystallised from dimethylformamide, with the addition of animal charcoal. 1.1 pts. by wt. (38.5%) of 1-(5-bromofurfurylideneamino)-2,3-dioxo-piperazine are obtained as yellowish crystals of decomp. pt. 220°.

후처리

  1. filtrationThe precipitate is filtered off
  2. washwashed with 3 pts
  3. customby vol. of glacial acetic acid and recrystallised from dimethylformamide, with the addition of animal charcoal

출처 및 근거

ORD 기록
ord-cb56760e2339460492f6caaafb119889
출처 데이터셋
uspto-grants-1980_01
특허 번호
US04182762

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