Formic Acid → N-(2-Benzoyl-4-chlorophenyl)formamide

반응식

[NH2:1][C:2]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[CH:17](O)=[O:18]>>[C:4]([C:3]1[CH:12]=[C:13]([Cl:16])[CH:14]=[CH:15][C:2]=1[NH:1][CH:17]=[O:18])(=[O:5])[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

참가 물질

반응물 2

HCID 284Formic Acid

HCID 128702-Amino-5-chlorobenzophenone

생성물 1

HCID 82576N-(2-Benzoyl-4-chlorophenyl)formamide수율 93%

실험 절차

A mixture of 100 g (0.43 mole) of 2-amino-5-chlorobenzophenone and 500 g formic acid was refluxed for 1 hr, and then cooled and poured into 1 l. of ice water. The solid that precipitated was collected on a filter, washed with water, dried in air, and recrystallized from heptane-benzene to give 103.5 g (93%) of the formamide as colorless crystals, mp 89°-91°.

후처리

temperaturewas refluxed for 1 hr
temperaturecooled
additionpoured into 1 l
customThe solid that precipitated
customwas collected on a filter
washwashed with water
customdried in air
customrecrystallized from heptane-benzene

출처 및 근거

ORD 기록: ord-c3fd0cb660f64c7fa657c58979406a5e
출처 데이터셋: uspto-grants-1980_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04182760

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