HCID 22809705, 화합물 → HCID 22809701, 화합물

HRID 2051820노트

반응식

HRID 2051820 반응식
[Cl:1][CH2:2][CH2:3][NH:4][C:5]([N:7]([CH:19]([CH2:21][CH3:22])[CH3:20])[CH:8]1[O:16][C@H:15]([CH2:17][OH:18])[C@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6].[N:23]([O-])=[O:24].[Na+]>C(O)=O>[Cl:1][CH2:2][CH2:3][N:4]([N:23]=[O:24])[C:5]([N:7]([CH:19]([CH2:21][CH3:22])[CH3:20])[CH:8]1[O:16][C@H:15]([CH2:17][OH:18])[C@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6]

참가 물질

4

반응물 2

HCID 22809705HCID 22809705, 화합물HCID 23668193Sodium Nitrite

생성물 1

HCID 22809701HCID 22809701, 화합물수율 22.4%

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

7.0 g of 1-(2-chloroethyl)-3-sec.butyl-3-D-galactopyranosylurea are dissolved in 20 ml of formic acid, and 5.0 g of sodium nitrite are added gradually thereto at 0° to 5° C. for one hour under stirring. The mixture is further stirred at the same temperature for one hour. After the reaction, the mixture is treated in the same manner as described in Example 5-(2). 1.7 g of 1-(2-chloroethyl)-1-nitroso-3-sec.butyl-3-D-galactopyranosylurea are thereby obtained as pale yellow caramel.

후처리

  1. stirringThe mixture is further stirred at the same temperature for one hour
  2. customAfter the reaction
  3. additionthe mixture is treated in the same manner

출처 및 근거

ORD 기록
ord-b0fadd03a7964a278abafdc1f4fa3136
출처 데이터셋
uspto-grants-1980_01
특허 번호
US04182757

반응 노트

불러오는 중…