Maleic Acid → HCID 70585028, 화합물

HRID 2052472노트

반응식

HRID 2052472 반응식
[NH2:1][C:2]1[C:17]([Br:18])=[CH:16][C:15]([Br:19])=[CH:14][C:3]=1[CH2:4][NH:5][C@H:6]([C:11]([OH:13])=[O:12])[CH2:7][CH2:8][S:9][CH3:10].[C:20]([OH:27])(=[O:26])/[CH:21]=[CH:22]\[C:23]([OH:25])=[O:24]>C(O)(=O)C>[C:20]([OH:27])(=[O:26])/[CH:21]=[CH:22]\[C:23]([OH:25])=[O:24].[NH2:1][C:2]1[C:17]([Br:18])=[CH:16][C:15]([Br:19])=[CH:14][C:3]=1[CH2:4][NH:5][C@H:6]([C:11]([OH:13])=[O:12])[CH2:7][CH2:8][S:9][CH3:10]

참가 물질

4

반응물 2

HCID 444266Maleic AcidHCID 13340374N-[(2-Amino-3,5-dibromophenyl)methyl]-L-methionine

생성물 1

HCID 70585028HCID 70585028, 화합물수율 84%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
20 °C

실험 절차

100 gm of N-(2-amino-3.5-dibromo-benzyl)-methionine were dissolved in 500 ml of hot acetic acid, and then, while stirring and heating the solution at the boiling point, 28 gm of maleic acid were added. After it had dissolved, the solution was cooled to 20° C. while stirring was continued, and the precipitated product was centrifuged off, washed with a little acetic acid and then with isopropylic acid, and after drying at 60° C. in a ventilated drying chamber, 107 gm of the desired product were obtained in the form of white crystals, which melted at 205° C.

후처리

  1. additionwere added
  2. dissolutionAfter it had dissolved
  3. stirringwhile stirring
  4. washwashed with a little acetic acid
  5. customwith isopropylic acid, and after drying at 60° C. in
  6. customa ventilated drying chamber

출처 및 근거

ORD 기록
ord-01ef2efad7d14fa9b8b9cfdf5926dfaf
출처 데이터셋
uspto-grants-1980_01
특허 번호
US04185114

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