Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 4-{[3-(2-Methoxyphenyl)propyl]amino}benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Ethyl 4-{[3-(2-methoxyphenyl)propyl]amino}benzoate | HCID 13079682 | — |
| 반응물 | Water ethanol | HCID 19096565 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-{[3-(2-Methoxyphenyl)propyl]amino}benzoic acid | HCID 13079681 | — |
반응 단계
A mixture of 7.0 g. of ethyl p-[3-(o-methoxyphenyl)propyl]aminobenzoate (prepared as described in Example 41), 7.0 g. of potassium hydroxide and 100 ml. of ethanol-water (9:1) is refluxed for 3.5 hours, acidified while hot with concentrated hydrochloric acid, diluted with water and chilled. The mixture is filtered and the solid washed with water to give off-white crystals, m.p. 155°-157° C. Recrystallization from ethanol gives off-white crystals, m.p. 156°-158° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04185115 |
| 출처 데이터셋 | uspto-grants-1980_01 |
| ORD ID | ord-1c56575e201a4db698c13055124c6982 |
| 출처 메모 | uspto-grants-1980_01 |