Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzocaine → Ethyl 4-{[3-(4-chlorophenyl)propyl]amino}benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzocaine | HCID 2337 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Hexamethylphosphoramide | HCID 12679 | — |
| 반응물 | 3-(4-Chlorophenyl)propyl methanesulfonate | HCID 13079705 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Ethyl 4-{[3-(4-chlorophenyl)propyl]amino}benzoate | HCID 13079692 | — |
반응 단계
A solution of 49.5 g. of ethyl 4-aminobenzoate, 34.9 g. of 3-(p-chlorophenyl)propanol O-mesylate in 100 ml. of hexamethylphosphoramide is heated at 125°-130° C. for 16 hours. The solution is diluted with 50 ml. of tetrahydrofuran and with 150 ml. of water. Chilling and filtering gives crystals which are washed with water and recrystallized from ethanol to give 28.3 g. of light yellow crystals. Recrystallizations give the product as crystals, m.p. 122°-124° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04185115 |
| 출처 데이터셋 | uspto-grants-1980_01 |
| ORD ID | ord-393350e9c5234997b8aa07446456191c |
| 출처 메모 | uspto-grants-1980_01 |