Ethyl Bromide → 5-(Ethylamino)-2-methylphenol

HRID 2052526노트

반응식

HRID 2052526 반응식
[CH2:1](Br)[CH3:2].[NH2:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:12])=[C:9]([OH:11])[CH:10]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C.O>[CH2:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:12])=[C:9]([OH:11])[CH:10]=1)[CH3:2]

참가 물질

6

반응물 3

HCID 6332Ethyl BromideHCID 10340Sodium CarbonateHCID 178185-Amino-2-methylphenol

생성물 1

HCID 158012485-(Ethylamino)-2-methylphenol

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

88.6 gm of ethyl bromide were added to a solution of 50 gm of 5-amino-2-methylphenol in 250 ml of ethanol; and the mixture was refluxed for four hours. After the solution had cooled, it was diluted with 1.2 liters of water and was made weakly alkaline with sodium carbonate. After repeated extraction with ether, the ether extracts were dried and concentrated. The residue was recrystallized from ethanol, and had a melting point of 128° C. to 129° C.

후처리

  1. temperatureand the mixture was refluxed for four hours
  2. temperatureAfter the solution had cooled
  3. extractionextraction with ether
  4. dry with materialthe ether extracts were dried
  5. concentrationconcentrated
  6. customThe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-f30ad37330bc41f895fe9d47caa7b121
출처 데이터셋
uspto-grants-1980_01
특허 번호
USRE030199

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