Dimethylformamide → 2,3-bis(4-methoxyphenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole

HRID 2052679노트

반응식

HRID 2052679 반응식
CN(C)C=O.Br[CH:7]([C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)[C:8]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)=O.[NH2:26][C:27]1[CH2:31][CH2:30][CH2:29][N:28]=1>O>[CH3:17][O:16][C:13]1[CH:14]=[CH:15][C:10]([C:8]2[N:26]=[C:27]3[CH2:31][CH2:30][CH2:29][N:28]3[C:7]=2[C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)=[CH:11][CH:12]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 3441532-Bromo-1,2-bis(4-methoxyphenyl)ethanoneHCID 127789042-Amino-1-pyrroline

생성물 1

HCID 12815562,3-bis(4-methoxyphenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 300 ml of dry N,N-dimethylformamide was added 30. g (0.09 mol) of 2-bromo-1,2-di(4-methoxyphenyl)ethanone and 19.5 g (0.27 mol) of 2-amino-4,5-dihydro-3H-pyrrole. The mixture was stirred for three days at 25° with the exclusion of moisture. The reaction mixture was poured into water and the aqueous suspension was extracted three times with methylene chloride. The organic extracts were combined and washed six times with water, then dried (K2CO3). The solvent was evaporated and the residue was recrystallized from chloroform-hexane and dried overnight (80° in vacuo) to give the title compound, m.p. 146°-147.5°.

후처리

  1. extractionthe aqueous suspension was extracted three times with methylene chloride
  2. washwashed six times with water
  3. dry with materialdried (K2CO3)
  4. customThe solvent was evaporated
  5. customthe residue was recrystallized from chloroform-hexane
  6. customdried overnight (80° in vacuo)

출처 및 근거

ORD 기록
ord-08191bfd8ed249808f2354f250ab9e8a
출처 데이터셋
uspto-grants-1980_01
특허 번호
US04186205

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