5-Fluoroorotic acid monohydrate → 5-Fluorouracil

HRID 2052724노트

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HRID 2052724 반응식
O.C(O)(=O)C1NC(=O)NC(=O)C=1.O.[F:14][C:15]1[C:23](=[O:24])[NH:22][C:21](=[O:25])[NH:20][C:16]=1C(O)=O>>[F:14][C:15]1[C:23](=[O:24])[NH:22][C:21](=[O:25])[NH:20][CH:16]=1

참가 물질

3

반응물 2

HCID 162127495-Fluoroorotic acid monohydrateHCID 162185041,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid monohydrate

생성물 1

HCID 33855-Fluorouracil

반응 조건

온도
260 °C

실험 절차

In the reaction, the conversion of the orotic acid monohydrate was 100% and the yield of 5-fluoro-orotic acid monohydrate was 85.0%. The crystals were heated at 260° C. under a reduced pressure of lower than 1 mmHg to perform the decarboxylation to obtain 22.5 g of 5-fluorouracil.

후처리

  1. customIn the reaction

출처 및 근거

ORD 기록
ord-efbca071b4d343cf9aff19e00611d2dd
출처 데이터셋
uspto-grants-1980_01
특허 번호
US04186266

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