Ammonia → HCID 178513829, 화합물

반응식

C[O:2][C:3]([C:5]1[N:10]=[C:9]([OH:11])[CH:8]=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[N:6]=1)=O.[NH3:22]>>[OH:11][C:9]1[CH:8]=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[N:6]=[C:5]([C:3]([NH2:22])=[O:2])[N:10]=1

참가 물질

반응물 2

HCID 222Ammonia

HCID 178499130HCID 178499130, 화합물

생성물 1

HCID 178513829HCID 178513829, 화합물

실험 절차

4-Hydroxy-6-(3-trifluoromethylphenyl)-pyrimidine-2-carboxylic acid methyl ester (17 mg) was stirred for one hour at room temperature in aqueous ammonia (500 ul). Solvent was evaporated under reduced pressure to yield product 4-hydroxy-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carboxylic acid amide (17 mg) as a white solid. 1H NMR (DMSO): δ 8.66 (s, 1H), 8.61 (s, 1H), 8.54 (d, 1H), 8.13 (s, 1H), 7.87 (d, 1H), 7.73 (t, 1H), 7.22 (s, 1H).

후처리

customSolvent was evaporated under reduced pressure

출처 및 근거

ORD 기록: ord-b985de625c954174a4f6f1a3f5e1784a
출처 데이터셋: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07326715B2

반응 노트

불러오는 중…