phenylmethyl 1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxylate → 1-(Morpholine-4-carboxamido)cyclohexanecarboxylic acid

HRID 2053465노트

반응식

HRID 2053465 반응식
[N:1]1([C:7]([NH:9][C:10]2([C:16]([O:18]CC3C=CC=CC=3)=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>CO.[Pd]>[N:1]1([C:7]([NH:9][C:10]2([C:16]([OH:18])=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

참가 물질

4

반응물 1

HCID 17851014phenylmethyl 1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxylate

생성물 1

HCID 115071371-(Morpholine-4-carboxamido)cyclohexanecarboxylic acid수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

In methanol was suspended 151 g (452 mmol) of phenylmethyl 1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxylate, 15 g of 5% palladium-active carbon was added to the suspension and the mixture was stirred under hydrogen stream at room temperature overnight. After removing the catalyst by filtration, the catalyst was washed three times with a mixed solvent of chloroform-methanol, and the organic layers were combined and the solvent was distilled off under reduced pressure to obtain 112 g (Yield: 100%) of the title compound.

후처리

  1. additionwas added to the suspension
  2. customAfter removing the catalyst
  3. filtrationby filtration
  4. washthe catalyst was washed three times with a mixed solvent of chloroform-methanol
  5. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-e509c080f01141928822e4ee4c7550fa
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07326799B2

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