Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2053526생성일: 2026년 10월 25일
4-Fluorobenzylamine → tert-butyl (4S,5R)-2-[(4-fluorophenyl)methylamino]-4,5-diphenyl-4,5-dihydroimidazole-1-carboxylate
https://huagongshe.com/reaction/2053526
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Fluorobenzylamine | HCID 67326 | — |
| 반응물 | cis-4,5-Diphenyl-2-methylthio-4,5-dihydro-imidazole-1-carboxylic Acid, Tert-Butyl Ester | HCID 86596320 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | tert-butyl (4S,5R)-2-[(4-fluorophenyl)methylamino]-4,5-diphenyl-4,5-dihydroimidazole-1-carboxylate | HCID 68568680 | 41.6% |
반응 단계
A mixture of intermediate 59 (1.0 g, 0.0027 mol), 4-fluorobenzylamine (0.372 mL, 0.00321 mol) and MeOH (0.4 mL) is heated at 100° C. for 2 days. The reaction mixture is cooled to RT, and partitioned between dichloromethane and water. The organic solution is separated, dried (MgSO4), and concentrated in vacuo. The residue is purified by chromatography on silica gel; gradient elution with heptane:EtOAc (80:20-40:60) gives 0.50 g of the product 85. 1H NMR (CDCl3) δ 7.60-7.35 (m, 3H), 7.15-6.90 (m, 10H), 6.85-6.70 (m, 2H), 5.50-5.30 (m, 2H), 5.75-5.55 (m, 2H), 1.12 (s, 9H); MS: m/z 446 (M++1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07326792B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_02 |
|---|
| ORD ID | ord-c8791c0e2c9448708eaf47ed6d2181c5 |
|---|
| 출처 메모 | uspto-grants-2008_02 |
|---|
