Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclohexanol → Ethyl (cyclohexyloxy)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclohexanol | HCID 7966 | — |
| 반응물 | Ethyl diazoacetate | HCID 12192 | — |
| 촉매 | Acetic acid, rhodium salt (4:2) | HCID 423677 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Ethyl (cyclohexyloxy)acetate | HCID 93856 | 887.3% |
반응 단계
To a solution of cyclohexanol (1.0 g, 0.95 mmol) in dichloromethane (30 mL) is added rhodium (II) acetate dimer (44 mg) followed by ethyl diazoacetate (1.14 g, 10.0 mmol). The reaction mixture is stirred at RT for 20 min. The reaction mixture is diluted with Et2O, filtered through celite, and the filtrate is evaporated and the residue is vacuum distilled at 150° C. to give 1.57 g of the product 407. 1H NMR (CDCl3) δ 4.23 (q, 2H), 4.10 (s, 2H), 3.33 (m, 1H), 1.93 (m, 2H), 1.74 (m, 2H), 1.54 (m, 1H), 1.4-1.1 (m, 8H)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07326792B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-972a465a4cfe4845a6f7c01ccee3d6f0 |
| 출처 메모 | uspto-grants-2008_02 |