Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl diazoacetate → (2-Phenoxy)ethoxyacetic Acid Ethyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl diazoacetate | HCID 12192 | — |
| 반응물 | Phenoxyethanol | HCID 31236 | — |
| 촉매 | Acetic acid, rhodium salt (4:2) | HCID 423677 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Heptane | HCID 8900 | — |
| 생성물 | (2-Phenoxy)ethoxyacetic Acid Ethyl Ester | HCID 33787264 | 82.8% |
반응 단계
To a solution of 2-phenoxyethan-1-ol (1.5 mL, 12.7 mmol) in dichloromethane (50 mL) is added rhodium (II) acetate dimer (10 mg) followed by ethyl diazoacetate (1.1 mL, 10.5 mmol). The reaction mixture is stirred at rt overnight. The reaction mixture is diluted with heptane, and filtered. The filtrate is evaporated, and the residue vacuum distilled to give 1.95 g of the product 440. 1H NMR (CDCl3) δ 7.40-7.25 (m, 2H), 7.10-6.90 (m, 3H), 4.30-4.15 (m, 5H), 4.15-4.05 (m, 1H), 4.05-3.90 (s, 2H), 1.28 (t, 3H)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07326792B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-d6f55f5ffb6a416888dd3964d6aa3c44 |
| 출처 메모 | uspto-grants-2008_02 |