Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylmorpholine → 3-bromo-N-[(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxyethyl]-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | 3-Bromo-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid | HCID 69309865 | — |
| 반응물 | Bromine chlorine | HCID 131726752 | — |
| 반응물 | HCID 178495727 | HCID 178495727 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | 3-bromo-N-[(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxyethyl]-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzamide | HCID 178495734 | 83% |
반응 단계
Prepared analogously to Example 1g from 3-bromo-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid, TBTU, N-methylmorpholine, and (1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxyethylamine in N,N-dimethylformamide. Yield: 83%; Rf value: 0.41 (silica gel; dichloromethane/methanol=95:5); C22H20BrClN4O3 (503.79); mass spectrum: (M+H)+=503/505/507 (bromine/chlorine isotope).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07326791B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-56c29bd79e7c404b9a5ddb88d2de9b5f |
| 출처 메모 | uspto-grants-2008_02 |