Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-amino-5-methyl-1H-pyrazole-4-carbonitrile → 2-Methyl-5-(4-trifluoromethyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-amino-5-methyl-1H-pyrazole-4-carbonitrile | HCID 227460 | — |
| 반응물 | 4,4,4-Trifluoro-1-(4-trifluoromethylphenyl)-1,3-butanedione | HCID 10859020 | — |
| 생성물 | 2-Methyl-5-(4-trifluoromethyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 86598658 | 63.2% |
반응 단계
Reaction of 1-(4-trifluoromethyl-phenyl)-4,4,4-trifluoro-butane-1,3-dione (284 mg, 1.0 mmol), prepared from commercially available 4-trifluoromethyl-acetophenone according to general procedure A, and commercially available 3-amino-4-cyano-5-methyl-pyrazole (122 mg, 1.0 mmol) according to general procedure B yielded the title compound as a light yellow solid (234 mg, 63%). MS (ISP) 371.1 [(M+H)+]; mp 184° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07329662B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-30200895b3c6463abd85eb24ebeba7ff |
| 출처 메모 | uspto-grants-2008_02 |