1-(4-Chlorophenyl)-4,4,4-trifluorobutane-1,3-dione → HCID 67213132, 화합물

HRID 2054240노트

반응식

HRID 2054240 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10](=O)[C:11]([F:14])([F:13])[F:12])=[CH:4][CH:3]=1.[NH2:17][C:18]1[C:22]([C:23]2[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=2)=[CH:21][NH:20][N:19]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:11]([F:14])([F:13])[F:12])[N:19]3[N:20]=[CH:21][C:22]([C:23]4[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=4)=[C:18]3[N:17]=2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 27738321-(4-Chlorophenyl)-4,4,4-trifluorobutane-1,3-dioneHCID 178509259HCID 178509259, 화합물

생성물 1

HCID 67213132HCID 67213132, 화합물수율 72%

실험 절차

Reaction of 1-(4-chloro-phenyl)-4,4,4-trifluoro-butane-1,3-dione (125 mg, 0.5 mmol), prepared from commercially available 4-chloro-acetophenone according to general procedure A, and 3-amino-4-(4-pyridinyl)-pyrazole [CAS No. 216661-87-9; prepared from 4-cyanomethyl-pyridine as described in Bioorg. Med. Chem. Lett. 12 (2002) 3537-3541] (80 mg, 0.5 mmol) according to general procedure B yielded the title compound as a yellow solid (135 mg, 72%). MS (ISP) 375.3 [(M+H)+]; mp 274° C.

출처 및 근거

ORD 기록
ord-2ebcd57f1a834af4b0af9a292ded77e6
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07329662B2

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