Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(3,4-Dichlorophenyl)-4,4,4-trifluorobutane-1,3-dione → 5-(3,4-Dichloro-phenyl)-3-pyridin-4-yl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(3,4-Dichlorophenyl)-4,4,4-trifluorobutane-1,3-dione | HCID 12446255 | — |
| 반응물 | HCID 178509259 | HCID 178509259 | — |
| 생성물 | 5-(3,4-Dichloro-phenyl)-3-pyridin-4-yl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine | HCID 67213174 | 46% |
반응 단계
Reaction of 1-(3,4-dichloro-phenyl)-4,4,4-trifluoro-butane-1,3-dione (285 mg, 1.0 mmol), prepared from commercially available 3,4-dichloro-acetophenone according to general procedure A, and 3-amino-4-(4-pyridinyl)-pyrazole [CAS No. 216661-87-9; prepared from 4-cyanomethyl-pyridine as described in Bioorg. Med. Chem. Lett. 12 (2002) 3537-3541] (160 mg, 1.0 mmol) according to general procedure B yielded the title compound as a yellow solid (94 mg, 46%). MS (ISP) 409.2 [(M+H)+]; mp 260° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07329662B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-1eef92ec1601424c97fc663b671dd3fc |
| 출처 메모 | uspto-grants-2008_02 |