3-Acetylpyridine → 2-Pyridin-3-yl-4-trifluoromethyl-imidazo[1,5-a]pyrimidine-8-carbonitrile

HRID 2054310

반응식

HRID 2054310 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7](=O)[CH2:8][C:9](=O)[C:10]([F:13])([F:12])[F:11])[CH:2]=1.C(C1C=NC=CC=1)(=O)C.[NH2:25][C:26]1[N:27]=[CH:28][NH:29][C:30]=1[C:31]#[N:32]>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:8]=[C:9]([C:10]([F:13])([F:12])[F:11])[N:27]3[CH:28]=[N:29][C:30]([C:31]#[N:32])=[C:26]3[N:25]=2)[CH:2]=1

참가 물질

4

반응물 3

HCID 95893-AcetylpyridineHCID 684951,3-Butanedione, 4,4,4-trifluoro-1-(3-pyridinyl)-HCID 787775-amino-1H-imidazole-4-carbonitrile

생성물 1

HCID 672131042-Pyridin-3-yl-4-trifluoromethyl-imidazo[1,5-a]pyrimidine-8-carbonitrile수율 13%

실험 절차

Reaction of 1-pyridin-3-yl-4,4,4-trifluoro-butane-1,3-dione (217 mg, 1.0 mmol), prepared from commercially available 3-acetylpyridine according to general procedure A, and 4-amino-5-cyano-1H-imidazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as a yellow solid (37 mg, 13%). MS (ISP) 290.1 [(M+H)+]; mp 222° C.

출처 및 근거

ORD 기록
ord-cc8076483d6c4a0888efdaa733ddafbb
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07329662B2

연결된 노트

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