Potassium Hydroxide → 2-bromo-4,5-dimethylaniline

HRID 2054450노트

반응식

HRID 2054450 반응식
[OH-].[K+].[Br:3][C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([CH3:11])=[CH:6][C:5]=1[NH:12]C(=O)C>CO>[Br:3][C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([CH3:11])=[CH:6][C:5]=1[NH2:12]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 890424N-(2-Bromo-4,5-dimethylphenyl)acetamide

생성물 1

HCID 41792362-bromo-4,5-dimethylaniline

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
80 °C

실험 절차

Potassium hydroxide (15.9 g, 284 mmol) was added to a stirred solution of N-2-bromo-4,5-dimethylphenyl)acetamide (1-7) (17.2 g, 71.0 mmol) in methanol (350 mL) at ambient temperature. After stirring at approximately 80° C. for 18 h, the reaction mixture was cooled and the organic volatiles removed in vacuo. The remaining aqueous phase was diluted with additional water (65 mL) and the resultant solid product was filtered, washed with water and dried in vacuo to afford 1-8 as a white solid.

후처리

  1. temperaturethe reaction mixture was cooled
  2. customthe organic volatiles removed in vacuo
  3. additionThe remaining aqueous phase was diluted with additional water (65 mL)
  4. filtrationthe resultant solid product was filtered
  5. washwashed with water
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-b23d21ac48cb423aa72ae0ca5e22959a
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07329673B2

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