Ethylamine → 2-(Ethylamino)-4-(3-diethylamino-1-propoxy)nitrobenzene

HRID 2054539

반응식

HRID 2054539 반응식
F[C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][CH2:11][N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[CH:5]=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18].[CH2:20]([NH2:22])[CH3:21]>C1COCC1>[CH2:20]([NH:22][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][CH2:11][N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[CH:5]=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18])[CH3:21]

참가 물질

4

반응물 2

HCID 6341EthylamineHCID 220147332-Fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene

생성물 1

HCID 220147352-(Ethylamino)-4-(3-diethylamino-1-propoxy)nitrobenzene수율 88%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene (2 mmol; preparation described in Example 5) in THF (5 mL) is treated with ethylamine (4 mmol) at rt. After completion of the reaction, the reaction mixture is concentrated in vacuo. The residue is redissolved in EtOAc (10 mL), washed with saturated sodium bicarbonate solution, water, and brine. The organic phase is then dried over sodium sulfate and the solvent is removed in vacuo to afford the product, 2-(ethylamino)-4-(3-diethylamino-1-propoxy)nitrobenzene (520 mg) which was used for further transformation without further purification.

후처리

  1. customAfter completion of the reaction
  2. concentrationthe reaction mixture is concentrated in vacuo
  3. dissolutionThe residue is redissolved in EtOAc (10 mL)
  4. washwashed with saturated sodium bicarbonate solution, water, and brine
  5. dry with materialThe organic phase is then dried over sodium sulfate
  6. customthe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-b13505da5f0a44f9b98e159f1213e58e
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07329684B2

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