3,5-Dimethylaniline → 3-(3,5-Dimethylphenyl)amino-4-nitrophenol

HRID 2054629

반응식

HRID 2054629 반응식
F[C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH3:12][C:13]1[CH:14]=[C:15]([CH:17]=[C:18]([CH3:20])[CH:19]=1)[NH2:16]>C(OCC)(=O)C>[CH3:12][C:13]1[CH:14]=[C:15]([NH:16][C:2]2[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=2[N+:8]([O-:10])=[O:9])[CH:17]=[C:18]([CH3:20])[CH:19]=1

참가 물질

4

반응물 2

HCID 79493,5-DimethylanilineHCID 5209483-Fluoro-4-nitrophenol

생성물 1

HCID 219381543-(3,5-Dimethylphenyl)amino-4-nitrophenol

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
120 °C

실험 절차

5.4 g of 3-fluoro-4-nitrophenol and 4.3 ml of 3,5-dimethylaniline were mixed and stirred for 6 hours at 120° C. After cooling, it was taken up in ethyl acetate and water and extracted three times with 1N aqueous hydrochloric acid. The combined aqueous phases were extracted three times with ethyl acetate. The combined organic phases were dried on sodium sulfate, concentrated by evaporation in a vacuum, and the residue was crystallized.

후처리

  1. temperatureAfter cooling
  2. extractionwater and extracted three times with 1N aqueous hydrochloric acid
  3. extractionThe combined aqueous phases were extracted three times with ethyl acetate
  4. customThe combined organic phases were dried on sodium sulfate
  5. concentrationconcentrated by evaporation in a vacuum
  6. customthe residue was crystallized

출처 및 근거

ORD 기록
ord-aefc4f6bdadd41ef8f4eb405ebd21e51
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07329679B2

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