Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2054682생성일: 2026년 10월 27일
Water → 5-[[(4-Chlorophenyl)sulfonyl][1,2-diphenyl-1H-benzimidazol-5-yl]amino]pentanoic acid methyl ester
https://huagongshe.com/reaction/2054682
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Methyl 5-bromovalerate | HCID 79557 | — |
| 반응물 | 4-Chloro-N-(1,2-diphenyl-1H-benzimidazol-5-yl)benzenesulfonamide | HCID 21938028 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-[[(4-Chlorophenyl)sulfonyl][1,2-diphenyl-1H-benzimidazol-5-yl]amino]pentanoic acid methyl ester | HCID 67365751 | — |
반응 단계
100 mg of 4-chloro-N-(1,2-diphenyl-1H-benzimidazol-5-yl)benzenesulfonamide was suspended in 0.5 ml of N,N-dimethylformamide, mixed with 8 mg of sodium hydride and stirred for 30 minutes at 20° C. 60 mg of 5-bromopentanoic acid methyl ester was added, it was allowed to stir for 15 hours, mixed with water, extracted three times with ethyl acetate, the extracts were dried on sodium sulfate, concentrated by evaporation in a vacuum, and the residue was chromatographed on silica gel.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07329679B2 |
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| 출처 데이터셋 | uspto-grants-2008_02 |
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| ORD ID | ord-093756bd495f4a1a8d850c12e09c4121 |
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| 출처 메모 | uspto-grants-2008_02 |
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