Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → {4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Isoquinoline-1-carboxylic acid | HCID 68092 | — |
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | 1-(2-(4-Fluorophenyl)ethyl)piperazine | HCID 11254522 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | {4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone | HCID 9885359 | — |
반응 단계
0.9 g of 1,1′-carbonyldiimidazole is added to a solution of 1 g of isoquinoline-1-carboxylic acid in 100 ml of tetrahydrofuran (THF), and the mixture is stirred at room temperature for 2 hours. 1.6 g of 1-[2-(4-fluorophenyl)ethyl]piperazine and 2.4 ml of triethylamine are added to this mixture, which is stirred for a further 80 hours. ConventionaL work-up gives {4-[2-(4-fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07329749B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-0e1702a7d52d463ea9f47c16268678c6 |
| 출처 메모 | uspto-grants-2008_02 |