참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2,4,6-Trifluorobenzonitrile | HCID 737177 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2,6-Difluoro-4-(morpholin-4-yl)benzonitrile | HCID 11528682 | 68.6% |
반응 단계
To a solution of 1.0 g (6.37 mmol) of 2,4,6-trifluorobenzonitrile in MeOH (25 mL) was added 0.6 mL (6.9 mmol) of morpholine and 1.2 mL (6.7 mmol) of N,N-diisopropylethylamine. The mixture was heated to 50° C. for 6 h then cooled to room temperature and diluted with H2O which caused a solid to precipitate from solution. The white solid was collected by filtration, washed with H2O and dried under vacuum to provide 0.98 g (68%) of 2,6-difluoro-4-morpholin-4-yl-benzonitrile as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07329764B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_02 |
|---|
| ORD ID | ord-f2505ceb71034e728e2a4655b9a619a7 |
|---|
| 출처 메모 | uspto-grants-2008_02 |
|---|
