Cyanuric chloride → HCID 59656634, 화합물

HRID 2054909노트

반응식

HRID 2054909 반응식
[NH2:1][C:2]1[C:3]2[C:13]([O:14][CH:15]3[CH2:18][CH2:17][CH2:16]3)=[CH:12][CH:11]=[C:10]([C:19]([NH2:21])=O)[C:4]=2[S:5][C:6]=1[C:7]([NH2:9])=[O:8].N1C(Cl)=NC(Cl)=NC=1Cl>CN(C=O)C.O>[NH2:1][C:2]1[C:3]2[C:13]([O:14][CH:15]3[CH2:18][CH2:17][CH2:16]3)=[CH:12][CH:11]=[C:10]([C:19]#[N:21])[C:4]=2[S:5][C:6]=1[C:7]([NH2:9])=[O:8]

참가 물질

5

반응물 2

HCID 7954Cyanuric chlorideHCID 11301190Benzo[b]thiophene-2,7-dicarboxamide, 3-amino-4-(cyclobutyloxy)-

생성물 1

HCID 59656634HCID 59656634, 화합물수율 48.1%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

To a stirred solution of the above amide (200 mg, 0.655 mmol) in DMF (3 mL) was added cyanuric chloride (60 mg, 0.325 mmol). The reaction was stirred at room temperature for 1 h. The mixture was slowly diluted with water (10 mL) and extracted with dichloromethane. The aqueous phase was allowed to stand for two weeks then the precipitate formed was collected by filtration, rinsed with MeOH and dried in vacuo to give the title compound (93.5 mg, 0.315 mmol, 48.1%).

후처리

  1. extractionextracted with dichloromethane
  2. waitto stand for two weeks
  3. customthe precipitate formed
  4. filtrationwas collected by filtration
  5. washrinsed with MeOH
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-f01a7c06250f46ffaf6f80cb87feb27d
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07329764B2

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