Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → 2-(Morpholin-4-ylmethyl)-5-nitroquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Bromomethyl-5-nitroquinoline | HCID 21948849 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-(Morpholin-4-ylmethyl)-5-nitroquinoline | HCID 21948800 | — |
반응 단계
460 mg (1.72 mmol) of 2-bromomethyl-5-nitroquinoline and 0.54 ml (6.2 mmol) of morpholine are dissolved in 150 ml of toluene. After 1.07 g (7.74 mmol) of potassium carbonate is added, the reaction mixture is allowed to reflux for 2 hours. Potassium carbonate is filtered off, and the filtrate is concentrated by evaporation. After purification on silica gel with hexane-ethyl acetate (0-100%), 190 mg (40% of theory) of the product is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07329753B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-791d296a7b4d4d38abdcdeb174c73b6b |
| 출처 메모 | uspto-grants-2008_02 |