7-Nitrobenzo[d][1,3]dioxole-4-carboxylic acid → 7-Amino-1,3-dioxaindane-4-carboxylic acid

HRID 2055019노트

반응식

HRID 2055019 반응식
[N+:1]([C:4]1[C:9]2[O:10][CH2:11][O:12][C:8]=2[C:7]([C:13]([OH:15])=[O:14])=[CH:6][CH:5]=1)([O-])=O.[H][H]>C(O)C.[Pd]>[NH2:1][C:4]1[C:9]2[O:10][CH2:11][O:12][C:8]=2[C:7]([C:13]([OH:15])=[O:14])=[CH:6][CH:5]=1

참가 물질

5

반응물 2

HCID 219488047-Nitrobenzo[d][1,3]dioxole-4-carboxylic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 219488227-Amino-1,3-dioxaindane-4-carboxylic acid수율 98.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

8.05 g of 7-nitro-benzo[1,3]dioxole-4-carboxylic acid is reacted with hydrogen in 650 ml of ethanol with 800 mg of palladium/carbon catalyst under normal pressure at room temperature. It is filtered through diatomaceous earth and concentrated by evaporation in a vacuum. 6.82 g of 7-amino-benzo[1,3]dioxole-4-carboxylic acid is obtained as a brown solid, flash point 196-197° C.

후처리

  1. filtrationIt is filtered through diatomaceous earth
  2. concentrationconcentrated by evaporation in a vacuum

출처 및 근거

ORD 기록
ord-1c81d56428284659b175840058fee591
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07329753B2

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