N-benzyloxy-N-{4,4-dimethyl-1-[N'-(4-trifluoromethyl-pyrimidin2-yl)-hydrazinocarbonyl]-cyclohexylmethyl}-formamide → N-{4,4-Dimethyl-1-[N'-(4-trifluoromethyl-pyrimidin-2-yl)-hydrazinocarbonyl]-cyclohexylmethyl}-N-hydroxy-formamide

HRID 2055211노트

반응식

HRID 2055211 반응식
C([O:8][N:9]([CH2:12][C:13]1([C:21]([NH:23][NH:24][C:25]2[N:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:28]=[CH:27][N:26]=2)=[O:22])[CH2:18][CH2:17][C:16]([CH3:20])([CH3:19])[CH2:15][CH2:14]1)[CH:10]=[O:11])C1C=CC=CC=1>CO.[Pd]>[CH3:19][C:16]1([CH3:20])[CH2:17][CH2:18][C:13]([CH2:12][N:9]([OH:8])[CH:10]=[O:11])([C:21]([NH:23][NH:24][C:25]2[N:30]=[C:29]([C:31]([F:34])([F:32])[F:33])[CH:28]=[CH:27][N:26]=2)=[O:22])[CH2:14][CH2:15]1

참가 물질

4

반응물 1

HCID 86606478N-benzyloxy-N-{4,4-dimethyl-1-[N'-(4-trifluoromethyl-pyrimidin2-yl)-hydrazinocarbonyl]-cyclohexylmethyl}-formamide

생성물 1

HCID 11749590N-{4,4-Dimethyl-1-[N'-(4-trifluoromethyl-pyrimidin-2-yl)-hydrazinocarbonyl]-cyclohexylmethyl}-N-hydroxy-formamide수율 74%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of N-benzyloxy-N-{4,4-dimethyl-1-[N′-(4-trifluoromethyl-pyrimidin2-yl)-hydrazinocarbonyl]-cyclohexylmethyl}-formamide (0.11 g, 0.23 mmol) in methanol (10 mL) was added 10% Pd/C (0.032 g). The reaction mixture was subjected to hydrogenation for 1 h at room temperature. The reaction mixture was then filtered through a pad of Celite@, and washed with methanol (20 mL). Removal of the solvent provided the title compound as a white solid (0.066 g, 74%). MH+390.

후처리

  1. filtrationThe reaction mixture was then filtered through a pad of Celite@
  2. washwashed with methanol (20 mL)
  3. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-8f2da3e3c4914c2b93f696f2a8940201
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07332485B2

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