Methyl[2-(pyridin-4-yl)ethyl]amine → 2-(N'-Pyrid-4-ylethyl-N'-methylureido)dibenzothiophene

HRID 2055308노트

반응식

HRID 2055308 반응식
[N+](C1C=CC(CO[C:10]([NH:12][C:13]2[CH:25]=[CH:24][C:16]3[S:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[C:15]=3[CH:14]=2)=[O:11])=CC=1)([O-])=O.[CH3:28][NH:29][CH2:30][CH2:31][C:32]1[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=1>CCOC(C)=O>[N:35]1[CH:36]=[CH:37][C:32]([CH2:31][CH2:30][N:29]([CH3:28])[C:10](=[O:11])[NH:12][C:13]2[CH:25]=[CH:24][C:16]3[S:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[C:15]=3[CH:14]=2)=[CH:33][CH:34]=1

참가 물질

4

반응물 2

HCID 143276Methyl[2-(pyridin-4-yl)ethyl]amineHCID 693158012-(4-Nitrobenzoxycarbonylamino)dibenzothiophene

생성물 1

HCID 98852872-(N'-Pyrid-4-ylethyl-N'-methylureido)dibenzothiophene

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

2-(4-Nitrobenzoxycarbonylamino)dibenzothiophene (Example 1; 501 mg, 1.35 mmol) was suspended in EtOAc (10 ml) and 4-[2-(methylamino)ethyl]pyridine (408 mg, 3.0 mol) added in one portion. The resulting mixture was stirred at ambient temperature for 16 hours then further EtOAc (50 ml) added. The solution was washed with 1 M sodium hydroxide (3×25 ml), water (2×25 ml) and brine (25 ml), dried and evaporated in vacuo. NMR 8.44 (m, 3H), 8.34 (d, 1H), 8.13 (m, 1H), 7.96 (m, 1H), 7.82 (d, 1H), 7.55 (dd, 1H), 7.47 (m, 2H), 7.28 (d, 2H), 3.61 (t, 2H), 2.96 (s, 3H), 2.86 (t, 2H); m/z 362.

후처리

  1. washThe solution was washed with 1 M sodium hydroxide (3×25 ml), water (2×25 ml) and brine (25 ml)
  2. customdried
  3. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-1ee63dc9aa99485c88110b08c5b9c7ae
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07332492B2

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