Ethyl 3-methyl-3-pyridin-4-ylprop-2-enoate → Ethyl 3-(pyridin-4-yl)butanoate
반응식
[CH3:1][C:2]([C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1)=[CH:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]>C(O)C.[Pd]>[CH3:1][CH:2]([C:9]1[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]참가 물질
4
실험 절차
To a solution of ethyl 3-methyl-3-pyridin-4-ylprop-2-enoate (Method 9; 8.4 g, 44 mmol) in ethanol (150 ml) was added 5% palladium on charcoal. The mixture was stirred under an atmosphere of hydrogen for 18 hours. The mixture was filtered through diatomaceous earth and the filtrate evaporated to leave a colourless oil. The crude product was purified by chromatography eluting with 30-50% EtOAc in hexane to give the product as a colourless oil. M/z 194.
후처리
- filtrationThe mixture was filtered through diatomaceous earth
- customthe filtrate evaporated
- customto leave a colourless oil
- customThe crude product was purified by chromatography
- washeluting with 30-50% EtOAc in hexane
출처 및 근거
- ORD 기록
- ord-01237831b77742c69eb72a6290e2cc20
- 출처 데이터셋
- uspto-grants-2008_02
- 특허 번호
- US07332492B2
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