Hydroxylamine → HCID 178495721, 화합물

HRID 20557

반응식

HRID 20557 반응식
[NH2:1][OH:2].[C:3]([C:5]1[CH:32]=[CH:31][C:8]([O:9][C:10]2[CH:11]=[C:12]([CH:22]=[C:23]([O:25][C@@H:26]([CH3:30])[CH2:27][O:28][CH3:29])[CH:24]=2)[C:13]([NH:15][C:16]2[CH:20]=[CH:19][N:18]([CH3:21])[N:17]=2)=[O:14])=[CH:7][CH:6]=1)#[N:4]>C(O)C>[OH:2][NH:1][C:3](=[NH:4])[C:5]1[CH:32]=[CH:31][C:8]([O:9][C:10]2[CH:11]=[C:12]([CH:22]=[C:23]([O:25][C@@H:26]([CH3:30])[CH2:27][O:28][CH3:29])[CH:24]=2)[C:13]([NH:15][C:16]2[CH:20]=[CH:19][N:18]([CH3:21])[N:17]=2)=[O:14])=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 787HydroxylamineHCID 116543663-(4-cyanophenoxy)-5-[(1S)-2-methoxy-(1-methylethyl)oxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

생성물 1

HCID 178495721HCID 178495721, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Hydroxylamine (50% w/w solution, 1 mL) was added to absolution of 3-(4-cyanophenoxy)-5-[(1S)-2-methoxy-(1-methylethyl)oxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide (300 mg, 0.74 mmol) in ethanol (3 mL) and the reaction mixture allowed to stir at RT for 18 hours. The volatiles were removed in vacuo to give the desired compound as a colourless foam (325 mg).

후처리

  1. customThe volatiles were removed in vacuo

출처 및 근거

ORD 기록
ord-7a6808c0ea414610b8722719b8b97a43
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745475B2

연결된 노트

불러오는 중…