Ethyl bromoacetate → HCID 11287642, 화합물

HRID 2056265노트

반응식

HRID 2056265 반응식
[OH:1][C:2]1[CH:6]=[C:5]([C:7]([O:9][CH3:10])=[O:8])[O:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]>CC(C)=O>[CH3:10][O:9][C:7]([C:5]1[O:4][N:3]=[C:2]([O:1][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:6]=1)=[O:8]

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 178498603HCID 178498603, 화합물

생성물 1

HCID 11287642HCID 11287642, 화합물수율 81%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of methyl 3-hydroxy-isoxazole-5-carboxylate (7.14 mmol) in acetone (30 mL), was added potassium carbonate (1.2 g, 8.6 mmol) and ethyl bromoacetate (8.6 mmol). The reaction mixture was heated at reflux for 2 h, monitoring by TLC. At completion, acetone was removed in vacuo and the residue partitioned between water and ethyl acetate (50 mL). The organic layer was dried (MgSO4), filtered, and evaporated to afford the desired intermediate.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 2 h
  3. customAt completion, acetone was removed in vacuo
  4. customthe residue partitioned between water and ethyl acetate (50 mL)
  5. dry with materialThe organic layer was dried (MgSO4)
  6. filtrationfiltered
  7. customevaporated

출처 및 근거

ORD 기록
ord-82811266ae484c7f923d9f075aa82098
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07335655B2

반응 노트

불러오는 중…