1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 135610070, 화합물

HRID 2056268노트

반응식

HRID 2056268 반응식
[C:1]([C:4]1[O:8][N:7]=[C:6]([O:9][CH2:10][C:11]([O:13]CC)=[O:12])[CH:5]=1)(O)=O.CCN=C=NCCCN(C)C.[CH2:27]([N:30]1[C:37]([NH2:38])=[C:36]([NH2:39])[C:34](=[O:35])[N:33]([CH2:40][CH2:41][CH3:42])[C:31]1=[O:32])[CH2:28][CH3:29]>CO>[CH2:40]([N:33]1[C:34](=[O:35])[C:36]2[NH:39][C:1]([C:4]3[O:8][N:7]=[C:6]([O:9][CH2:10][C:11]([OH:13])=[O:12])[CH:5]=3)=[N:38][C:37]=2[N:30]([CH2:27][CH2:28][CH3:29])[C:31]1=[O:32])[CH2:41][CH3:42]

참가 물질

5

반응물 3

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 50986055,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedioneHCID 58846560HCID 58846560, 화합물

생성물 1

HCID 135610070HCID 135610070, 화합물

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a solution of ethyl (5-carboxyisoxazol-3-yl)oxyacetate (0.5 mmol) and EDCI (0.5 mmol) in methanol (20 mL) was added a solution of 1,3-dipropyl-5,6-diaminouracil (0.5 mmol), dissolved in methanol (20 mL). The mixture was stirred at room temperature for two hours, the solvent was then removed in vacuo, water added, and the solid that formed was collected by filtration and washed with additional cold water. The intermediate amide was heated in 20 mL of 2.5 N NaOH at 70° C. for 30 minutes to afford the desired 2-[5-(1,3-dipropyl-xanthin-8-yl)-isoxazol-3-yloxy]acetic acid.

후처리

  1. customthe solvent was then removed in vacuo, water
  2. additionadded
  3. customthe solid that formed
  4. filtrationwas collected by filtration
  5. washwashed with additional cold water
  6. temperatureThe intermediate amide was heated in 20 mL of 2.5 N NaOH at 70° C. for 30 minutes

출처 및 근거

ORD 기록
ord-f404d52827924dd3a81d0a51ce07c851
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07335655B2

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