Triethylamine → Ethyl 4-methyl-2-(4-methylbenzoylamino)-3-oxopentanoate

HRID 2056387노트

반응식

HRID 2056387 반응식
Cl.[NH2:2][CH:3]([C:9](=[O:13])[CH:10]([CH3:12])[CH3:11])[C:4]([O:6][CH2:7][CH3:8])=[O:5].[CH3:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=1.C(N(CC)CC)C>ClCCl>[CH3:11][CH:10]([CH3:12])[C:9](=[O:13])[CH:3]([NH:2][C:19](=[O:20])[C:18]1[CH:22]=[CH:23][C:15]([CH3:14])=[CH:16][CH:17]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 134054-Methylbenzoyl ChlorideHCID 57434496Ethyl 2-amino-4-methyl-3-oxopentanoate hydrochloride

생성물 1

HCID 57434497Ethyl 4-methyl-2-(4-methylbenzoylamino)-3-oxopentanoate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

10 g of ethyl 2-amino-4-methyl-3-oxopentanoate hydrochloride and 7.4 g of 4-methylbenzoyl chloride are dissolved in 250 ml of dichloromethane, and 13.3 ml of triethylamine are slowly added dropwise at 0° C. The mixture is stirred at room temperature for one hour and then washed with water, the organic phase is separated off and dried over MgSO4, and the solvent is then removed under reduced pressure. This gives 13 g of ethyl 4-methyl-2-(4-methylbenzoylamino)-3-oxopentanoate as an oil. C16H21NO4 (291.35), MS(ESI)=292 (M+H+).

후처리

  1. washwashed with water
  2. customthe organic phase is separated off
  3. dry with materialdried over MgSO4
  4. customthe solvent is then removed under reduced pressure

출처 및 근거

ORD 기록
ord-33db2b0426de49beb34638da9aceb59b
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07335671B2

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